Paul D. Rainville

LCGC NA - The Quantification of Clopidogrel in Human Plasma

The method development process required for the accurate quantification of both clopidogrel and its acid metabolite with a lower limit of quantification (LLOQ) of 1 pg/mL in human plasma is discussed.

A discussion on the analytical challenges that both liquid chromatography and mass spectrometry face as well as some potential solutions to these issues.