PerkinElmer, Inc.

This note applies the EPA 1633 workflow to fish and animal tissues, enabling sensitive, low‑level PFAS detection using automated SPE and LC/MS/MS. The dual‑layer SPE design improves efficiency and recovery, meeting all EPA performance criteria across complex tissue matrices.

In food safety testing, instrument reliability under real-world conditions is the true test of performance. This technical note showcases the durability and consistency of the PerkinElmer QSight® 500 LC/MS/MS system through an intensive robustness study, analyzing high-matrix food samples with minimal cleanup and no loss in sensitivity. Using a simplified QuEChERS extraction (no SPE), the system successfully analyzed PFAS analytes across complex matrices like salmon, avocado, pet food, and spices. The results highlight not only long-term stability but also the power of StayClean™ technology to reduce downtime and keep throughput high.

This application note describes a fast and robust LC‑MS/MS method for honey authenticity testing by targeted quantification of 3‑methoxytyramine, a specific marker for beet‑sugar feeding. Using the QSight® 500 LC‑MS/MS with EDIT‑ESI and a simplified Blend‑and‑Inject workflow, the method eliminates SPE and isotopically labeled internal standards while delivering high sensitivity, excellent reproducibility, and high throughput for routine commercial and regulatory honey testing.

This application note presents a simplified Blend‑and‑Inject LC‑MS/MS method for the quantification of 25 PFAS compounds in animal‑derived food matrices using the QSight® 500 LC‑MS/MS system. By eliminating SPE and leveraging matrix‑matched calibration, isotopically labeled standards, and a PFAS delay column, the method achieves EU‑compliant sensitivity and robust performance in complex tissues, enabling high‑throughput and reliable PFAS monitoring for food safety compliance.

Fast GC/MS method analyzes 76 pesticides per EPA 525 in under 8.5 min using the PerkinElmer GC system, ensuring compliance, sensitivity, and resolution.

Fast GC/MS method for SVOC per EPA 8270E: 87 compounds analyzed in ~14 min with high accuracy, compliance, and repeatability

Webinar Date/Time: Tue, Apr 28, 2026 11:00 AM EDT

GC-FID enables fast, reproducible analysis of 37 FAMEs in edible oils, improving fatty acid profiling for quality, authenticity, and adulteration detection.

HS-GC-FID enables compliant residual solvent analysis per USP 467, delivering accurate quantitation, full separation, and improved productivity in pharma labs.

A robust HS-GC-FID workflow on the PerkinElmer GC system enables accurate, reproducible USP 467 residual solvent analysis with streamlined, 21 CFR Part 11–compliant data control.

Fast GC/MS method analyzes 76 pesticides per EPA 525 in under 8.5 min using the PerkinElmer GC system, ensuring compliance, sensitivity, and resolution.

Rapid HS-GC/FID method quantifies ethanol in food and drink with high sensitivity, robust calibration, and compliance across global standards.

GC-FID enables accurate benzene analysis in USP Carbomer 940, meeting system suitability and supporting compliant pharmaceutical quality control workflows.

Fast GC/MS method for SVOC per EPA 8270E: 87 compounds analyzed in ~14 min with high accuracy, compliance, and repeatability

Discover how the PET Recycling Team is setting new standards in recycled material performance using the GC 2400 systems to transform quality control process and accelerate your sustainability goals

Rapid HS-GC/FID method quantifies ethanol in food and drink with high sensitivity, robust calibration, and compliance across global standards.

Fast GC/MS method analyzes 76 pesticides per EPA 525 in under 8.5 min using GCMS 2400, ensuring compliance, sensitivity, and resolution.

Discover a robust GC headspace method for accurate, low-carryover detection of residual NMP in Li-ion batteries using the GC 2400 and HS 2400M systems.

Fast GC/MS method for SVOC per EPA 8270E: 87 compounds analyzed in ~14 min with high accuracy, compliance, and repeatability

A robust HS-GC-FID workflow on the GC 2400™ and HS 2400™ enables accurate, reproducible USP 467 residual solvent analysis with streamlined, 21 CFR Part 11–compliant data control.

Quantify 1,4-dioxane in water and cosmetics with trace-level accuracy using PerkinElmer's GCMS Headspace Sampler.

Download Part 4 to explore complete protocols, recovery data, and matrix-specific insights — closing out the full PFAS testing series.

Download Part 3 to explore complete method protocols, performance data, and insights for PFAS analysis in soils and sediments. Part 4 will cover PFAS analysis in fish and animal tissue samples.

Download Part 2 to explore proven workflows, SPE enhancements, and field-tested results. Stay tuned for Parts 3 and 4, covering tissue and solid matrix applications.

Download Part 1 now to explore method optimization strategies, validation protocols, and best practices for reliable PFAS quantification. Parts 2–4 will cover additional sample matrices including wastewater, animal tissue, solids, and biosolids.

Download the technical note to see how QSight redefines LC/MS/MS robustness for food labs handling PFAS analysis at scale.

Webinar Date/Time: Tue, Nov 18, 2025 11:00 AM EST

Discover how the PerkinElmer GC 2400™ Platform helps with the residual solvent in plastic with accuracy and sensitivity, providing reliable and reproducible runs for high throughput laboratories.