PerkinElmer, Inc.

Per‑ and polyfluoroalkyl substances (PFAS) are persistent environmental contaminants that can accumulate in animal‑derived foods, creating growing regulatory and public health concerns. Traditional PFAS testing methods often rely on time‑consuming solid‑phase extraction (SPE) and extensive cleanup to manage complex tissue matrices. This application note demonstrates a simplified, high‑throughput Blend & Inject LC‑MS/MS workflow using the PerkinElmer QSight® 500 LC‑MS/MS system for reliable PFAS quantification in animal‑derived food products while meeting stringent EU and EPA regulatory requirements.

PFAS rules now reach the packaging itself. Under the EU Packaging and Packaging Waste Regulation, food contact packaging containing 25 ng/g or more of any individual PFAS cannot be placed on the market, so labs need targeted data at production volume. This application note shows a Direct Shoot LC-MS/MS method on the PerkinElmer QSight 500 system that quantifies 26 PFAS in food packaging bottles, pharmaceutical packaging bottles and packaged drinking water. It uses a simple methanol extraction and no SPE cleanup. Calibration runs from 0.05 to 25 ng/g, with recoveries predominantly within 70 to 130%.

Recycled PET manufacturers need to prove their packaging is free of unwanted volatile contaminants without adding cost or complexity to their QC workflow. Acetaldehyde, benzene, and limonene are the three compounds regulators and converters watch most closely in rPET, and testing for them has traditionally required separate methods on separate instruments. This application note demonstrates a single HS-GC-MS method, using the PerkinElmer GCMS SQ 2400 System and HS 2400M Headspace Sampler, that quantifies all three compounds in one run, with strong precision, linearity, and recovery.

Flexible food packaging protects what's inside it, but the inks and adhesives used to print and laminate it can leave behind residual organic solvents. Those solvents can migrate into food, raising safety concerns and drawing scrutiny under regulations like EU 1935/2004 and GMP requirements in Commission No. 2023/2006. This application note demonstrates how the PerkinElmer GC 2400 System, paired with the HS 2400 M Headspace Sampler, quantifies 16 residual solvents in flexible food packaging with strong precision and accuracy.

GC-FID enables fast, reproducible analysis of 37 FAMEs in edible oils, improving fatty acid profiling for quality, authenticity, and adulteration detection.

GC-FID enables accurate benzene analysis in USP Carbomer 940, meeting system suitability and supporting compliant pharmaceutical quality control workflows.

Analyze residual solvents in flexible food packaging with GC 2400 and HS 2400 M, delivering accurate, compliant results and no carryover.

Effluent wastewater testing is essential for protecting human health and the environment, and EPA Method 624.1 is a widely used approach for monitoring volatile organic compounds (VOCs) in water. This application note demonstrates how the combination of the Teledyne LABS Tekmar Lumin Purge & Trap (P&T) concentrator, AQUATek LVA autosampler, and PerkinElmer GCMS 2400 platform delivers accurate, reliable, and highly sensitive VOC analysis while effectively managing water vapor transfer that can compromise GC/MS performance.

Dibenzyl disulfide (DBDS) is a corrosive sulfur compound that can accelerate copper sulfide formation in transformers, increasing the risk of insulation damage and equipment failure. Routine monitoring of DBDS is therefore critical for transformer health, regulatory compliance, and preventive maintenance. This application note demonstrates how the PerkinElmer GC 2400 System with Electron Capture Detection (ECD) provides a sensitive, reliable, and cost-effective approach for DBDS analysis in transformer oils, delivering excellent linearity, precision, and freedom from carryover in accordance with IEC 62697 guidelines.

This note applies the EPA 1633 workflow to fish and animal tissues, enabling sensitive, low‑level PFAS detection using automated SPE and LC/MS/MS. The dual‑layer SPE design improves efficiency and recovery, meeting all EPA performance criteria across complex tissue matrices.

In food safety testing, instrument reliability under real-world conditions is the true test of performance. This technical note showcases the durability and consistency of the PerkinElmer QSight® 500 LC/MS/MS system through an intensive robustness study, analyzing high-matrix food samples with minimal cleanup and no loss in sensitivity. Using a simplified QuEChERS extraction (no SPE), the system successfully analyzed PFAS analytes across complex matrices like salmon, avocado, pet food, and spices. The results highlight not only long-term stability but also the power of StayClean™ technology to reduce downtime and keep throughput high.

This application note describes a fast and robust LC‑MS/MS method for honey authenticity testing by targeted quantification of 3‑methoxytyramine, a specific marker for beet‑sugar feeding. Using the QSight® 500 LC‑MS/MS with EDIT‑ESI and a simplified Blend‑and‑Inject workflow, the method eliminates SPE and isotopically labeled internal standards while delivering high sensitivity, excellent reproducibility, and high throughput for routine commercial and regulatory honey testing.

This application note presents a simplified Blend‑and‑Inject LC‑MS/MS method for the quantification of 25 PFAS compounds in animal‑derived food matrices using the QSight® 500 LC‑MS/MS system. By eliminating SPE and leveraging matrix‑matched calibration, isotopically labeled standards, and a PFAS delay column, the method achieves EU‑compliant sensitivity and robust performance in complex tissues, enabling high‑throughput and reliable PFAS monitoring for food safety compliance.

Fast GC/MS method analyzes 76 pesticides per EPA 525 in under 8.5 min using the PerkinElmer GC system, ensuring compliance, sensitivity, and resolution.

Fast GC/MS method for SVOC per EPA 8270E: 87 compounds analyzed in ~14 min with high accuracy, compliance, and repeatability

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GC-FID enables fast, reproducible analysis of 37 FAMEs in edible oils, improving fatty acid profiling for quality, authenticity, and adulteration detection.

HS-GC-FID enables compliant residual solvent analysis per USP 467, delivering accurate quantitation, full separation, and improved productivity in pharma labs.

A robust HS-GC-FID workflow on the PerkinElmer GC system enables accurate, reproducible USP 467 residual solvent analysis with streamlined, 21 CFR Part 11–compliant data control.

Fast GC/MS method analyzes 76 pesticides per EPA 525 in under 8.5 min using the PerkinElmer GC system, ensuring compliance, sensitivity, and resolution.

Rapid HS-GC/FID method quantifies ethanol in food and drink with high sensitivity, robust calibration, and compliance across global standards.

GC-FID enables accurate benzene analysis in USP Carbomer 940, meeting system suitability and supporting compliant pharmaceutical quality control workflows.

Fast GC/MS method for SVOC per EPA 8270E: 87 compounds analyzed in ~14 min with high accuracy, compliance, and repeatability

Discover how the PET Recycling Team is setting new standards in recycled material performance using the GC 2400 systems to transform quality control process and accelerate your sustainability goals

Rapid HS-GC/FID method quantifies ethanol in food and drink with high sensitivity, robust calibration, and compliance across global standards.

Fast GC/MS method analyzes 76 pesticides per EPA 525 in under 8.5 min using GCMS 2400, ensuring compliance, sensitivity, and resolution.

Discover a robust GC headspace method for accurate, low-carryover detection of residual NMP in Li-ion batteries using the GC 2400 and HS 2400M systems.

Fast GC/MS method for SVOC per EPA 8270E: 87 compounds analyzed in ~14 min with high accuracy, compliance, and repeatability

A robust HS-GC-FID workflow on the GC 2400™ and HS 2400™ enables accurate, reproducible USP 467 residual solvent analysis with streamlined, 21 CFR Part 11–compliant data control.

Quantify 1,4-dioxane in water and cosmetics with trace-level accuracy using PerkinElmer's GCMS Headspace Sampler.