William Goodman | Authors

Polynuclear aromatic hydrocarbons (PAHs) are carcinogenic condensed ring aromatic compounds widely found as trace pollutants in waters, wastes, air particulates, soil and foods. PAHs can be routinely monitored using HPLC with a combination of UV and fluorescence detection as prescribed in EPA methods 550.1, 610 and 8310.

Melamine is an industrial chemical with a high nitrogen content that can cause kidney stones and lead to renal failure. In some instances, melamine has been added to baby formula and dairy products as a substitute for protein. This paper presents an efficient and definitive gas chromatography–mass spectrometry (GC–MS) method to identify melamine and related compounds based on the released US Food and Drug Administration (FDA) method.

Melamine is an industrial chemical with a high nitrogen content that can cause kidney stones and lead to renal failure. In some instances, melamine has been added to baby formula and dairy products as a substitute for protein. This paper presents an efficient and definitive gas chromatography–mass spectrometry (GC–MS) method to identify melamine and related compounds based on the released US Food and Drug Administration (FDA) method.

The United States Pharmacopeia (USP) has implemented a revised method for the determination of residual solvents, chapter 467; this revision has brought the methodology of USP 467 into close alignment with European Pharmacopeia (EP) method 2.4.24. The USP and EP determination of class 1 and class 2 residual solvents is performed with static headspace (HS) sample introduction and gas chromatography (GC) with flame ionization detection (FID); class 3 has flexibility in the technique, however, it is often included in the HS analysis.

Phthalates are added to plastics to increase flexibility. Recently, concerns have been raised over the effect of phthalate exposure from plastic materials on human health.

By William Goodman, PerkinElmer, Inc.