October 1st 2015
Here we highlight some of the opportunities associated with combining advanced sample preparation techniques with state-of-the-art chemical analysis techniques. This article considers the unique combination of selective pressurized liquid extraction (SPLE) with gas chromatography coupled with mass spectrometry (MS) and ultra-performance liquid chromatography coupled with tandem MS-MS (UPLC-MS-MS). We use this powerful combination to develop a novel analytical technique capable of measuring hormones and organic contaminants in whale earwax plugs. We explore the analytical challenges with such combinations and the advantages of focusing both on sample preparation as well as instrumentation associated with chemical analysis.