The Application Notebook
February 01, 2014
General
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The unique surface chemistry of the Flare diamond core-shell column combines ionic and hydrophobic separation mechanisms to effectively retain a variety of chemical species in a single run.
February 01, 2014
Medical/Biological
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High throughput analysis of amino acids has been a goal for both column and instrument manufacturers for many years.
February 01, 2014
Food and Beverage
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Polyether antibiotics are commonly used for preventing coccidiosis and other infections in poultry and for improving feed efficiency for beef cattle and swine.
February 01, 2014
Articles
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Gas chromatography with electron ionization and mass spectrometry (GC–EI-MS) detection is a workhorse among analytical techniques in metabolomics.
February 01, 2014
Food and Beverage
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In this application we demonstrate the analysis of coffee and coffee products according to DIN methods. The performance of the analysis is shown for linearity, limit of detection (LOD), limit of quantification (LOQ), retention time, and area precision.
February 01, 2014
Environmental
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Gas chromatography coupled to high resolution time-of-flight mass spectrometry (GC–HRT) was used to identify halogenated organic compounds based on their mass defects in fish tissue extracts.
February 01, 2014
General
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As the cost of helium increases and its availability decreases, an increasing number of Gas Chromatography (GC) professionals are considering switching to hydrogen gas for their carrier gas.
February 01, 2014
Articles
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Carbon nanotubes (CNTs) are cylindrical allotrope nanostructures of carbon with unique structures and unusual properties.
February 01, 2014
Pharmaceutical/Drug Discovery
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The ability to simultaneously collect quantitative and qualitative information from a DMPK analysis has the potential to significantly increase productivity in pharmaceutical drug discovery and development.
February 01, 2014
Medical/Biological
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Heparin is a polydisperse, heterogeneous polysaccharide derived from animal tissue. Heparin has been used as an anticoagulant for over 60 years and one of the fundamental parameters for characterizing unfractionated heparin (UFH) is its molecular weight (MW) and MW distribution.
February 01, 2014
Medical/Biological
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The use of UHPLC systems for small molecule analysis has gained widespread acceptance among researchers in recent years.
February 01, 2014
Food and Beverage
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Fusel alcohols, a common byproduct of fermentation, in abnormal quantities or types can indicate alcoholic beverage adulteration.
February 01, 2014
Articles
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Recent advances in sampling techniques in the pharmaceutical industry sparked significant interest in applying improvements to extraction methods for greater analyte detection and quantitation.
February 01, 2014
Environmental
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US EPA method 529 is the procedure to determine explosives and related compounds in finished drinking water.
February 01, 2014
General
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In mass spectrometry instrumentation, the sensitivity and resolution of the instrument is often limited by the detector.
February 01, 2014
Environmental
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Chromium (Cr) is a metal with an interesting relationship to the environment. Whereas trivalent chromium (Cr(III)) is an essential nutrient, hexavalent chromium (Cr(VI)) is a poison to humans and aquatic life and poses serious environmental and ecological threats.
February 01, 2014
Articles
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Many parameters within liquid chromatography–mass spectrometry (LC–MS) methods are "locked and left" - that is, they are optimized using a few methods when new, then only changed if absolutely necessary because of poor analytical performance.
February 01, 2014
Medical/Biological
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Analysis of polycarbonate urethanes (PCUs) are a class of biocompatible polyurethanes that show great promise for use in orthopedic implants, such as artificial hips.
February 01, 2014
Medical/Biological
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Ultra high performance liquid chromatography (UHPLC) continues to grow in popularity due to highly efficient columns and fast run times, which result in excellent resolution and high throughput.
February 01, 2014
Medical/Biological
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Monoamine neurotransmitters (adrenaline, dopamine, noradrenaline, and acetylcholine) are released from the brain and peripheral nervous system in minute amounts.
February 01, 2014
Environmental
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EPA 8270D calls for the extraction for analysis of semi-volatile analytes in various matrices. Target analytes mentioned in the method cover a wide range of compound classes resulting in reporting lists that often approach 100 compounds.
February 01, 2014
Environmental
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Laboratories taking in a high volume of aqueous semi-volatile samples know that every sample is different.
February 01, 2014
Pharmaceutical/Drug Discovery
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In the USP method for acetaminophen (1), the related compound p-aminophenol is determined using spectrophotometry while another related compound, p-chloroacetanilide, is determined using TLC.
February 01, 2014
Issue PDF
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Click the title above to open the LCGC North America February 2014 Application Notebook, Vol 32 No s2, in an interactive PDF format.