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The Application Notebook-02-01-2014
The Application Notebook
Separation of a Mix of Acidic, Basic, and Neutral Compounds at High pH Conditions
February 01, 2014
General
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The unique surface chemistry of the Flare diamond core-shell column combines ionic and hydrophobic separation mechanisms to effectively retain a variety of chemical species in a single run.
Ultra-High Throughput Amino Acid Analysis in Less Than One Minute
February 01, 2014
Medical/Biological
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High throughput analysis of amino acids has been a goal for both column and instrument manufacturers for many years.
Analysis of Polyether Antibiotics in Animal Feeds by HPLC with Post-Column Derivatization
February 01, 2014
Food and Beverage
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Polyether antibiotics are commonly used for preventing coccidiosis and other infections in poultry and for improving feed efficiency for beef cattle and swine.
Comprehensive Analysis of Human Plasma Using Gas Chromatography–High Resolution Time-of-Flight Mass Spectrometry: A Workflow to Leverage Electron and Chemical Ionization
February 01, 2014
Articles
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Gas chromatography with electron ionization and mass spectrometry (GC–EI-MS) detection is a workhorse among analytical techniques in metabolomics.
Analysis of Coffee and Coffee Products by HPLC for the Determination of Natural Components and Harmful Contamination
February 01, 2014
Food and Beverage
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In this application we demonstrate the analysis of coffee and coffee products according to DIN methods. The performance of the analysis is shown for linearity, limit of detection (LOD), limit of quantification (LOQ), retention time, and area precision.
Leveraging Mass Defect Plots for Compound Identification in Complex Matrices by GC-HRT
February 01, 2014
Environmental
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Gas chromatography coupled to high resolution time-of-flight mass spectrometry (GC–HRT) was used to identify halogenated organic compounds based on their mass defects in fish tissue extracts.
Considerations for Switching from Helium to Hydrogen for Gas Chromatography Carrier Gas
February 01, 2014
General
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As the cost of helium increases and its availability decreases, an increasing number of Gas Chromatography (GC) professionals are considering switching to hydrogen gas for their carrier gas.
Carbon Nanotubes: Applications in Chromatography and Sample Preparation
February 01, 2014
Articles
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Carbon nanotubes (CNTs) are cylindrical allotrope nanostructures of carbon with unique structures and unusual properties.
Simultaneous Quantitative and Qualitative Measurements in a Single Workflow to Increase Productivity in Primary Drug Metabolism Investigations
February 01, 2014
Pharmaceutical/Drug Discovery
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The ability to simultaneously collect quantitative and qualitative information from a DMPK analysis has the potential to significantly increase productivity in pharmaceutical drug discovery and development.
Molecular Weight Determination of Unfractionated Heparin
February 01, 2014
Medical/Biological
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Heparin is a polydisperse, heterogeneous polysaccharide derived from animal tissue. Heparin has been used as an anticoagulant for over 60 years and one of the fundamental parameters for characterizing unfractionated heparin (UFH) is its molecular weight (MW) and MW distribution.
UHPLC Separations Using HPLC Methods and TSKgel Columns
February 01, 2014
Medical/Biological
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The use of UHPLC systems for small molecule analysis has gained widespread acceptance among researchers in recent years.
Alcoholic Beverage Fusel Alcohol Testing with Static Headspace
February 01, 2014
Food and Beverage
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Fusel alcohols, a common byproduct of fermentation, in abnormal quantities or types can indicate alcoholic beverage adulteration.
Application of Paper Strip Extraction in Combination with LC–MS-MS in Pharmacokinetics
February 01, 2014
Articles
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Recent advances in sampling techniques in the pharmaceutical industry sparked significant interest in applying improvements to extraction methods for greater analyte detection and quantitation.
Determination of Explosives in Water Using a Novel Polymeric DVB Sorbent
February 01, 2014
Environmental
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US EPA method 529 is the procedure to determine explosives and related compounds in finished drinking water.
Recent Improvements in Time of Flight Mass Spectrometer Detection Technologies
February 01, 2014
General
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In mass spectrometry instrumentation, the sensitivity and resolution of the instrument is often limited by the detector.
Hexavalent Chromium Determination Hamilton PRP-X100 Anion Exchange HPLC Column
February 01, 2014
Environmental
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Chromium (Cr) is a metal with an interesting relationship to the environment. Whereas trivalent chromium (Cr(III)) is an essential nutrient, hexavalent chromium (Cr(VI)) is a poison to humans and aquatic life and poses serious environmental and ecological threats.
Optimizing LC–MS and LC–MS-MS Methods
February 01, 2014
Articles
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Many parameters within liquid chromatography–mass spectrometry (LC–MS) methods are "locked and left" - that is, they are optimized using a few methods when new, then only changed if absolutely necessary because of poor analytical performance.
Polycarbonate-Urethane Molar Mass Distributions
February 01, 2014
Medical/Biological
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Analysis of polycarbonate urethanes (PCUs) are a class of biocompatible polyurethanes that show great promise for use in orthopedic implants, such as artificial hips.
Improved SEC Separations Using TSKgel Columns on a UHPLC System
February 01, 2014
Medical/Biological
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Ultra high performance liquid chromatography (UHPLC) continues to grow in popularity due to highly efficient columns and fast run times, which result in excellent resolution and high throughput.
Analysis of Choline, Acetylcholine, and Monoamine Neurotransmitters by Polymer-Based Ion Chromatography and Mass Spectrometry
February 01, 2014
Medical/Biological
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Monoamine neurotransmitters (adrenaline, dopamine, noradrenaline, and acetylcholine) are released from the brain and peripheral nervous system in minute amounts.
The Automated Extraction of Aqueous Samples by Method EPA 8270D Using the TurboTrace ABN SPE System
February 01, 2014
Environmental
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EPA 8270D calls for the extraction for analysis of semi-volatile analytes in various matrices. Target analytes mentioned in the method cover a wide range of compound classes resulting in reporting lists that often approach 100 compounds.
Streamlining Sample Processing for Semi-Volatile Organics in the Most Challenging Water Samples
February 01, 2014
Environmental
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Laboratories taking in a high volume of aqueous semi-volatile samples know that every sample is different.
Modernizing the USP Monograph for Acetaminophen
February 01, 2014
Pharmaceutical/Drug Discovery
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In the USP method for acetaminophen (1), the related compound p-aminophenol is determined using spectrophotometry while another related compound, p-chloroacetanilide, is determined using TLC.
Vol 32 No 2 LCGC North America February 2014 Application Notebook PDF
February 01, 2014
Issue PDF
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Click the title above to open the LCGC North America February 2014 Application Notebook, Vol 32 No s2, in an interactive PDF format.