The Column-06-19-2015

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The Column

In developing countries, access to medicine is often limited. To make matters worse, widespread counterfeiting often means that even when patients get access to drugs, the drugs are of poor quality. Dr. Mélisande Bernard, of the Agence Générale des Equipements et Produits de Santé, the technical and pharmaceutical service of the public hospital system of Paris, France (Assistance Publique–Hôpitaux de Paris), is helping to address this problem by developing chromatographic methods to detect substandard cardiovascular drugs in Africa. She recently spoke to us about this work.

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The Column

Temperature affects not only retention but also relative retention in gas chromatography (GC) and therefore, when we change temperature, we also change the selectivity of the separation. This is true as we alter the isothermal separation temperature, but also as we change the slope of the temperature program gradient.

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The Column

A new study hopes to highlight that poison was used as far back as 30,000 years ago. Dr Valentina Borgia, a specialist in Palaeolithic hunting weapons and Marie Curie Fellow at the McDonald Institute for Archaeological Research at the University of Cambridge, is using liquid chromatography combined with mass spectrometry (LC–MS) to analyze prehistoric weaponry.

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The Column

Methadone, a drug prescribed for managing the symptoms of heroin withdrawal and chronic pain, has been linked to the formation of the carcinogenic compound N-Nitrosodimethylamine (NDMA) in drinking water. Understanding which compounds contribute to NDMA formation in water could lead to tailored wastewater treatment approaches to remove the risk of contamination.

The Column

Novasep (Pompey, France) has signed two partnership agreements with Allied Laboratories (Kobe, Japan) and AR Brown (Tokyo, Japan) to extend its presence in Japan.