The Column-07-22-2016

The Column

Waters Collaborates with BTI on Glycosphingolipid Project

July 22, 2016

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Waters Corporation has announced a collaboration with the Bioprocessing Technology Institute (BTI), a research institute within Singapore’s Agency for Science, Technology, and Research.

Researchers Use Chip CE to Investigate Rhinovirus Replication

July 22, 2016

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Researchers from Vienna University of Technology (TU Wien), Austria, have used chip capillary electrophoresis (CE) in combination with molecular beacons (MBs) to analyze the release of the RNA genome from a human rhinovirus.

The University of Manchester Opens Stoller Biomarker Discovery Centre

July 22, 2016

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The University of Manchester unveiled the £18-million Stoller Biomarker Discovery Centre at the beginning of June 2016. The research centre will focus on biomedical research on major diseases, including cancer, psoriasis, and arthritis, using mass spectrometry (MS)‑based proteomics solutions from Sciex.

The Value of Chemometrics and Experimental Design to Analytical Chemists

July 22, 2016

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Kevin A. Schug considers what the study of chemometrics and experimental design statistics can add to an analytical chemist’s work. Do analytical chemists lack an appreciation for the mathematical and statistical tools used to tease out important information?

Vol 12 No 13 The Column July 22, 2016 Europe and Asia PDF

July 22, 2016

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Click the title above to open The Column July 22, 2016 Europe & Asia issue, Volume 12, Number 13, in an interactive PDF format.

Vol 12 No 13 The Column July 22, 2016 North American PDF

July 22, 2016

Issue PDF

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Click the title above to open The Column July 22, 2016 North American issue, Volume 12, Number 13, in an interactive PDF format.

Urine Analysis: The Good, the Bad, and the Ugly

July 06, 2016

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In clinical and forensic/toxicology laboratories, urine is a preferred matrix from which to quantify drug concentrations because it yields accurate results and allows for noninvasive collection methods. Prior to excretion, drug metabolites in the body undergo a glucuronidation reaction, resulting in a glucuronide bond that must be cleaved before mass spectrometry (MS) analysis by a β-glucuronidase enzyme hydrolysis. Many laboratories employ a “dilute-and-shoot” method after hydrolysis to decrease residual protein or enzyme concentration, but this method negatively affects column lifetime and reduces the sensitivity of analyte detection. By using a β-glucuronidase removal approach, analysts are able to see an increase in sensitivity and a reduction in MS instrument maintenance.