The Column-07-26-2013

A cell cycle clock consisting of four continuous stages governs cell division (and replication), with each stage controlled by a specific series of protein complexes. Cancer is characterized by the uncontrolled division of cells that have gained genetic mutations that allow them to overcome these controls, therefore resulting in their self-sufficiency.

Scientists from the University of Michigan Medical Centre (Michigan, USA) have demonstrated the viability of immuno-laser capture microdissection (iLCM) combined with nano liquid chromatography tandem mass spectrometry (LC–MS–MS) for the investigation of various subpopulations of cells within tissues.1 Cancerous tissue can contain different subpopulations of cells and knowing what is within a tumour can help to determine the appropriate course of treatment.

The Column spoke to Professor Andrea Tapparo, of the University of Padova, Italy, about the use of chromatography to investigate declining honeybee populations.

This article examines the FFF technique with particular reference to the analyses of nanoparticles in food packaging.

The functional principles of AF4 and HF5 are discussed.

A new candidate biomarker of sugar and sugar-sweetened beverage (SSB) intake has been proposed in a recent study published in the Journal of Nutrition.1 The study presents the carbon isotope ratio of alanine as a new biomarker for use in studies monitoring dietary sugar intake

Incognito focuses on method validation and the importance of an internal standard to an analytical process.