LCGC Asia Pacific-06-01-2013

LCGC Asia Pacific

Gradient Elution, Part I: Intuition

June 01, 2013

Columns

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In contrast to isocratic separations, gradient elution can sometimes seem to be counter-intuitive. Yet with the proper perspective, the things we intuitively understand about isocratic methods apply in a similar manner to gradients.

Assay for ppm Levels of Azide in Drug Substances

June 01, 2013

Cover Story

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The removal of azide as a potential impurity from a drug substance may be critical to its safety profile. The quantitation of this impurity is an important control parameter. This article describes a simple and practical assay for azide using chemical derivatization and HPLC. The method is shown to be suitable for the intended purpose on three example test materials. Potential issues for wider applications are discussed.

Vol 16 No 2 LCGC Asia Pacific June 2013 Regular Issue PDF

June 01, 2013

Issue PDF

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Click the title above to open the LCGC Asia Pacific June 2013 regular issue, Vol 16, No 2, in an interactive PDF format.