LCGC Asia Pacific-06-01-2017

When you want to adjust a United States Pharmacopeia (USP) method for a different size column or to meet system suitability criteria that fail, how much of a change can you make without revalidating the method?

The quantitative extraction and subsequent purification of trace contaminants from (semi-)solid environmental and food matrices of regular size (that is, a few grams) is still recognized as a challenging task, typically accomplished through relatively complex off-line multistep treatment procedures. When these conventional sample preparation procedures are applied to the treatment of size-limited samples (of less than 1 g), the difficulties increase. This review discusses the different analytical strategies that can be adopted to overcome (or at least reduce) these difficulties when chromatographic techniques are involved for final instrumental determination.

An excerpt from LCGC’s e-learning tutorial on high performance liquid chromatography (HPLC) methods at CHROMacademy.com

In this instalment, John Hinshaw presents an annual review of new developments in the field of gas chromatography (GC) seen at Pittcon 2017 and other venues in the past year.

Click the title above to open the LCGC Asia Pacific June 2017 regular issue, Vol 20, No 2, in an interactive PDF format.