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LCGC Europe-06-01-2015
LCGC Europe
Translations Between Differing Liquid Chromatography Formats: Advantages, Principles, and Possible Pitfalls
June 12, 2015
Features
28
6
The numerous advantages of translating gradient chromatographic methods between the differing formats of LC have been explored and discussed. While translations in principle obey well defined chromatographic theories, the authors investigate a number of potential pitfalls that may result in poor translations as exhibited by selectivity differences, changes in efficiency, and hence failure to meet resolution system suitability criteria.
Current State of Superficially Porous Particle Technology in Liquid Chromatography
June 10, 2015
Column Watch
28
6
The use of superficially porous particles (SPPs) in the manufacture of high performance liquid chromatography (HPLC) columns has become prominent in recent years. Over the course of the past decade most major manufacturers have built column lines around the technology. At the recent Pittcon conference in New Orleans, Louisiana, USA, a large number of oral and poster presentations centred on the current research and advances using superficially porous particles. This instalment aims to provide some highlights of these recent trends.
The 5th International Network of Environmental Forensics 2015 (INEF 2015) Conference
June 10, 2015
Departments
28
6
The 5th International Network of Environmental Forensics (INEF) 2015 conference will be held from 3–6 August 2015 at Victoria College at the University of Toronto, Ontario, Canada.
Questions of Quality: Where Can I Draw The Line?
June 01, 2015
Questions of Quality
28
6
Where Can I Draw The Line?
Internal Standard Calibration Problems
June 01, 2015
LC Troubleshooting
28
6
Readers’ questions regarding problems related to internal standard calibration of liquid chromatography methods are addressed.
Separation Science in Drug Development, Part 1: High-Throughput Purification
June 01, 2015
Perspectives in Modern HPLC
28
6
This instalment provides an overview of modern practices of high-throughput purification to support small-molecule drug discovery. It describes the use of reversed-phase liquid chromatography (LC) and supercritical fluid chromatography (SFC) for purifying diverse samples in a centralized laboratory setting. A case study is used to illustrate the principles and rationales for selecting operating parameters for these applications. This is the first instalment of four articles on “Separation Science in Drug Development” to describe the modern practice of separation science in supporting small-molecule drug discovery and development.
Vol 28 No 6 LCGC Europe June 2015 Regular Issue PDF
June 01, 2015
Issue PDF
28
6
Click the title above to open the LCGC Europe June 2015 regular issue, Vol 28, No 6, in an interactive PDF format.