LCGC Europe-11-01-2015

LCGC Europe

A Decade of Quantitating Cyanide in Aqueous and Blood Matrices Using Automated Cryotrapping Isotopic Dilution Static Headspace GC–MS

November 30, 2015

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Paul R. Loconto shares his insights into the principles and practice of implementing and improving upon the original method to quantitate cyanide at trace concentration levels in human blood matrices using automated cryogenic trapping isotope dilution static headspace gas chromatography–mass spectrometry (GC–MS).

What Is “Dead” Volume and Why Should Chromatographers Worry About It?

November 01, 2015

Columns

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The term dead volume often comes up in chromatography discussions and literature. This month we address the nature of this phenomenon, when it can become a problem that affects chromatographic results, and how to understand and take control of it.

What’s In a Name?

November 01, 2015

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Primary record is a term that was defined by the MHRA (Medicines and Healthcare products Regulatory Agency, the UK drug regulator) in data integrity guidance issued in 2015. In this instalment of Questions of Quality we explore what this term means in practice, and compare it with raw data in the European Union Good Manufacturing Practices (EU GMPs) and complete data in US Food and Drug Administration (FDA) GMPs. Why can’t we have harmonization of terms?

Hamish Small: Experimenter Extraordinaire

November 01, 2015

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Hamish Small spoke to AndrО Striegel about the secrets of his success in separation science, including the development of ion chromatography, and the value of vague thoughts in scientific progress.

A Decade of Quantitating Cyanide in Aqueous and Blood Matrices Using Automated Cryotrapping Isotopic Dilution Static Headspace GC-MS

November 01, 2015

Features

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Paul R. Loconto shares his insights into the principles and practice of implementing and improving upon the original method to quantitate cyanide at trace concentration levels in human blood matrices using automated cryogenic trapping isotope dilution static headspace gas chromatography-mass spectrometry (GC-MS).

Vol 28 No 11 LCGC Europe November 2015 Regular Issue PDF

November 01, 2015

Issue PDF

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Click the title above to open the LCGC Europe November 2015 regular issue, Vol 28, No 11, in an interactive PDF format.