LCGC Europe-11-01-2015

Paul R. Loconto shares his insights into the principles and practice of implementing and improving upon the original method to quantitate cyanide at trace concentration levels in human blood matrices using automated cryogenic trapping isotope dilution static headspace gas chromatography–mass spectrometry (GC–MS).

An excerpt from LCGC’s e-learning tutorial on UV detection for HPLC at CHROMacademy.com

How to get started in the process of identifying the problem source for column-related problems.

The term dead volume often comes up in chromatography discussions and literature. This month we address the nature of this phenomenon, when it can become a problem that affects chromatographic results, and how to understand and take control of it.

Primary record is a term that was defined by the MHRA (Medicines and Healthcare products Regulatory Agency, the UK drug regulator) in data integrity guidance issued in 2015. In this instalment of Questions of Quality we explore what this term means in practice, and compare it with raw data in the European Union Good Manufacturing Practices (EU GMPs) and complete data in US Food and Drug Administration (FDA) GMPs. Why can’t we have harmonization of terms?

Hamish Small spoke to AndrО Striegel about the secrets of his success in separation science, including the development of ion chromatography, and the value of vague thoughts in scientific progress.

An excerpt from LCGC’s e-learning tutorial on UV detection for HPLC at CHROMacademy.com

Paul R. Loconto shares his insights into the principles and practice of implementing and improving upon the original method to quantitate cyanide at trace concentration levels in human blood matrices using automated cryogenic trapping isotope dilution static headspace gas chromatography-mass spectrometry (GC-MS).

Click the title above to open the LCGC Europe November 2015 regular issue, Vol 28, No 11, in an interactive PDF format.