September 2024

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An Integrative Analytical Quality by Design (AQbD), Up-To-Date Greenness, and Whiteness Set of Tools for Evaluation of a Sustainable RP-HPLC Method for Regulated Products

An Integrative Analytical Quality by Design (AQbD), Up-To-Date Greenness, and Whiteness Set of Tools for Evaluation of a Sustainable RP-HPLC Method for Regulated Products

Jerome Workman Jr.
September 16th 2024
ArticleColumns

In this interview, we asked Hemanth Kumar Chanduluru from the SRM Institute of Science and Technology in Kattankulathur, India, multiple questions regarding sustainability in analytical separation methods.

Glass vial, pipette and woman scientist in laboratory for medical study, research or experiment. Test tube, dropper and professional female person with chemical liquid for pharmaceutical innovation. | Image Credit: © peopleimages.com - stock.adobe.com

Are You Sure You Understand USP <621>?

Paul Smith;R.D. McDowall
September 16th 2024
ArticleColumn: Questions of Quality

In this column, we look at the current version and the update of USP <621> on high-performance liquid chromatography (HPLC) that becomes effective 1st May 2025.

Scientist moved the vial of sample out from the tray autosampler of the Liquid Chromatography Mass Spectrometer LC/MS after the analysis was complete. | Image Credit: © S. Singha - stock.adobe.com

In-Loop Analyte Degradation in Two-Dimensional Liquid Chromatography: Example and Solutions

Ziqing Lin;Qinggang Wang;Dwight R. Stoll
September 13th 2024
ArticleColumn: LC Troubleshooting

In this installment of “LC Troubleshooting,” we describe an artifact that can arise because of compound degradation during the transfer of fractions of the first dimension (1D) column effluent to the 2D separation.

Nicholas H. Snow is the Founding Endowed Professor in the Department of Chemistry and Biochemistry at Seton Hall University, and an Adjuncy Professor of Medical Science. During his 30 years as a chromatographer, he has published more than 70 refereed articles and book chapters and has given more than 200 presentations and short courses. He is interested in the fundamentals and applications of separation science, especially gas chromatography, sampling, and sample preparation for chemical analysis. His research group is very active, with ongoing projects using GC, GC-MS, two-dimensional GC, and extraction methods including headspace, liquid-liquid extraction, and solid-phase microextraction. Direct correspondence to: LCGCedit@mmhgroup.com

Optimizing Splitless Injections in Gas Chromatography, Part 1: What It Is and What Happens When We Inject

Nicholas H. Snow
September 13th 2024
ArticleGC Connections

For trace quantitative analysis, the splitless technique is most used as an inlet capable of performing both split and splitless injections. In this and upcoming installments, we take a closer look at splitless injection.

Denver Skyline | Image Credit: © fredb709 - stock.adobe.com

Highlights from the 52nd International Symposium on High Performance Liquid Phase Separations and Related Techniques (HPLC 2024)

Cory E. Muraco
September 12th 2024
ArticleColumn: Column Watch

This “Column Watch” installment presents many of the highlighted topics and trends observed at the 52nd International Symposium on High Performance Liquid Phase Separations and Related Techniques (HPLC 2024).

Vol 1 No 8 LCGC International September 2024 Europe PDF

Vol 1 No 8 LCGC International September 2024 Europe PDF

September 6th 2024
Article

Click here to access the LCGC International September 2024 Europe PDF in an interactive format.