Nicholas H. Snow | Authors

A review of the history and fundamentals for determining and reporting limit of detection (LOD) for analytical instruments and methods. Includes a discussion of the International Union of Pure and Applied Chemistry (IUPAC) and propagation of errors methods used for calculating LOD, and explains the limitations of the IUPAC method in modern chromatography.

The limit of detection (LOD) of an analytical method may be defined as the smallest concentration of analyte that has a signal significantly greater than that of a blank sample signal. We explore the sources of experimental uncertainty and variability in LOD determinations.

We present our annual review of new products in gas chromatography, introduced between spring 2020 and spring 2021.

“GC Connections” presents the column’s annual review of new developments in the field of gas chromatography seen at Pittcon and other venues in the past 12 months.