LCGC North America-09-01-2006

LCGC North America
GC Connections

September 01, 2006

September 2006. The accuracy and precision of results in gas chromatography and other analytical techniques are highly dependent upon the sample and its preparation, the instrumentation, accessories, and operating conditions, as well as on operator skill and experience. For these reasons, accuracy and precision for a specific methodology can be expected to vary from one laboratory or operator to another. This month, we look at statistical analysis as a diagnostic tool.

LCGC North America
LC Troubleshooting

September 01, 2006

John Dolan addresses two column-related problems reported by readers - the first deals with a column that takes several injections to "settle down" for each batch of samples while the second problem relates to short column life due to early fouling of the column.

LCGC North America
Directions in Discovery

September 01, 2006

September 2006. Top-down and bottom-up are alternative strategies for protein identification and characterization by mass spectrometry. How do they fit into the world of proteomics? What are their implications for separation technology? These questions are addressed in this installment of "Directions in Discovery."

LCGC North America
Departments

September 01, 2006

The market for high performance liquid chromatography (HPLC) continues to be one of the most dynamic markets of the analytical instruments industry. A few years ago, the HPLC market began showing signs of maturity with little product innovation and slower growth rates. Although innovations in mass spectrometry (MS) helped to fuel growth, HPLC was an afterthought and considered to be a mere inlet to MS. However, the recent development of fast liquid chromatography (LC) systems is energizing the HPLC market.

LCGC North America
Peer-Reviewed Article

September 01, 2006

September 2006. In analytical chemistry, the continual quest for enhanced sensitivity and specificity - in gas chromatography (GC), this can be equated to separation power - remain the common goal in the development of new analytical methodologies. Today, GC is still the most widely used method for the analysis of volatile and semivolatile organic compounds. When coupled with the right choice of detector for the specific application, a wide linearity range and low limit of detection (LOD) can be met. For GC analyses, many approaches can be used to achieve greater sensitivity and lower LOD. They can be classified broadly into four categories: improved sampling (sample preparation) strategies; sample introduction methods; improved chromatographic performance; and alternative (selective–sensitive) detection transducers. This article provides an up-to-date review of existing and emerging chromatographic innovations, based upon these four strategies, that will improve sensitivity and detection limits of trace..

LCGC North America
Column Watch

September 01, 2006

The popular HPLC 2006 Symposium was held in June in San Francisco, California. It is the premier annual meeting in liquid phase separations technology.

Departments
LCGC North America

September 01, 2006

Sigma-Aldrich Corp. (St. Louis, Missouri) has acquired Pharmorphix, Ltd. (Cambridge, United Kingdom) that offers solid-form research services to pharmaceutical and biotech markets. Terms of the acquisition were not disclosed.