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LCGC North America-10-01-2017

LCGC North America

All is Well That Ends Well

October 01, 2017

LC Troubleshooting

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In his final column before retirement, John Dolan reflects on the changes he has seen during his 34 years as the author of “LC Troubleshooting,” and shares his short list of best practices that still hold true today.

Resolving the Complexity of Biomacromolecules Using Multiple Modes of Chromatography

October 01, 2017

Column Watch

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To resolve and quantitate monoclonal antibodies and antibody–drug conjugates, analytical scientists need various chromatographic modes, such as sizeexclusion, ion-exchange, hydrophobic interaction, and hydrophilic interaction chromatography. Here, we provide advice for making the most of each mode.

Advancing Food Analysis with Ultrahigh-Pressure Liquid Chromatography and High-Resolution Mass Spectrometry

October 01, 2017

Focus on Food Analysis

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Liquid Chromatography and High-Resolution Mass Spectrometry In food analysis, HPLC and triple-quadrupole mass spectrometry are established techniques. Jon Wong of the Center for Food Safety and Applied Nutrition at the U.S. Food and Drug Administration discusses why his agency and others have been developing food analysis methods using UHPLC and HRMS.

Five Things You May Not Know About GC

October 01, 2017

The Essentials

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These five tips could improve your for gas chromatography methods.

34 Years of LC Troubleshooting: An Interview with John Dolan

October 01, 2017

Special Feature

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Dwight Stoll, who will take the reins of “LC Troubleshooting” next month, spoke with John Dolan to get some insight on the current state of chromatography with John Dolan to get some insight on the current state of chromatography training, future troubleshooting problems, John’s toughest troubleshooting challenge, and the most common chromatographic mistakes.

Using Benzoyl Chloride Derivatization to Improve Small-Molecule Analysis in Biological Samples by LC–MS/MS

October 01, 2017

Peer-Reviewed Article

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In metabolomics, LC–MS is a popular technique because of its ability to separate a wide range of metabolites, but the presence of many highly polar analytes in these samples poses a challenge. Benzoyl chloride derivatization can be a practical solution, improving both sensitivity and selectivity.

Vol 35 No 10 LCGC North America October 2017 Regular Issue PDF

October 01, 2017

Issue PDF

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Click the title above to open the LCGC North America October 2017 regular issue, Vol 35 No 10, in an interactive PDF format.