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LCGC North America-12-01-2007

LCGC North America

The Perfect Method, Part VII: The Gradient Shortcut

December 01, 2007

LC Troubleshooting

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For the last six months, "LC Troubleshooting" has been concentrating on the process for the development of isocratic methods (those for which the mobile phase composition is constant throughout the run). The use of a gradient scouting run to speed isocratic method development is the subject of this month?s "LC Troubleshooting."

Peaks of Interest

December 01, 2007

Departments

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Millipore Corporation (Billerica, Massachusetts) announced the availability of the new Milli-Q Integral water purification system, which uses tap water to supply constant-quality Type II (pure) and Type I (ultrapure) water from a single water production unit.

Impurity Determinations for Biotechnology-Derived Biopharmaceuticals and Related Products

December 01, 2007

Validation Viewpoint

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This installment of "Validation Viewpoint" column addresses, in the hopes of clarifying what the biopharmaceutical industry is required to do today to identify and quantify impurities in their biotech, proteinaceous products.

Incipient Technologies: Desorption and Thermal Desorption Techniques

December 01, 2007

MS - The Practical Art

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Nearly a dozen incipient technologies have appeared in recent years. Which will survive? Which will find extensive, robust usage as did electrospray ionization? Which are fated to become footnotes in mass spectrometry practice?

Thin Layer Chromatography

December 01, 2007

Departments

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Thin layer chromatography (TLC) is a planar chromatographic technique introduced in the 1950s as a fast, easy, and inexpensive method for qualitative analysis. Just as with column chromatography, the chemistry and size of the particles (as well as the thickness of the layer) affects the speed and nature of the separations that are possible.

Immunosorbents for Selective Sample Preparation of Complex Mixtures

December 01, 2007

Sample Prep Perspectives

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In this month?s installment, columnist Ron Majors covers the field of immunoextraction, a technique that employs immobilized antibodies to selectively capture specific analytes using molecular recognition via antibody?antigen interactions. Recently, the introduction of commercial products for specific high-volume environmental and food safety applications has spurred further applications of this technique.