LCGC North America-12-01-2015
LCGC North America
Nontargeted Metabolite Profiling in Next-Generation Plant Breeding: A Case Study in Malting Barley
December 01, 2015
MS–The Practical Art
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Non-targeted metabolite profiling by ultrahigh-performance liquid chromatography coupled with mass spectrometry (UHPLC–MS) is a powerful technique to investigate the influence of genetic and environmental influence on metabolic phenotype in plants. The approach offers an unbiased and in-depth analysis that can reveal molecular markers of desirable phenotypic traits which can be complementary to genetic markers in plant breeding efforts. Here, the power of non-targeted metabolite profiling is illustrated in a study focused on the determination of molecular markers in malting barley that are predictive of desirable malting quality for brewing applications.
The Ideal Chromatography Data System for a Regulated Laboratory, Part III: Essential Chromatographic Functions for Electronic Ways of Working
December 01, 2015
Peer Reviewed Article
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In the first two parts of this series we have looked at where and how a CDS fitted into a regulated laboratory and the overall requirements for the architecture of a future system. In this part we focus on new electronic ways of working for chromatographic analysis.
Guest Editorial: Handing Over the Reins
December 01, 2015
Guest Editorial
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A farewell letter from long-time LCGC columnist Ron Majors.
Detective Work, Part II: Physical Problems with the Column
December 01, 2015
LC Troubleshooting
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Particulate matter from the sample or the system can cause havoc in the chromatogram.
Preparing Eluents for HPLC—What You Ought to Know
December 01, 2015
The Essentials
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A short guide to the do’s, don’ts and gotcha’s of eluent preparation for everyday HPLC
Separation Science in Drug Development, Part IV: Quality Control
December 01, 2015
Perspectives in Modern HPLC
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This fourth and last installment in the series of “Separation Science in Drug Development” provides an overview of modern practices of Quality Control in small molecule drug development including activities such as setting specifications, method validation/transfer, release and stability testing, and authoring CMC sections of regulatory filings.
Future Needs of HPLC and UHPLC Column Technology
December 01, 2015
Column Watch
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In his final “Column Watch” article, Ron Majors looks into his crystal ball and discusses future needs in the area of HPLC/UHPLC column technology and related instrumentation. He looks at where current technology may be heading and makes a prediction that monolith-based columns may still have a rightful place in the HPLC/UHPLC laboratory .This article concludes his duration as a monthly columnist for LCGC.
In Memory of Roy Eksteen
December 01, 2015
Special Feature
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A tribute to Roy Eksteen, who was a great man and a great proponent of the chromatographic sciences.
Vol 33 No 12 LCGC North America December 2015 Regular Issue PDF
December 01, 2015
Issue PDF
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Click the title above to open the LCGC North America December 2015 regular issue, Vol 33 No 12, in an interactive PDF format.