LCGC North America-12-01-2015

LCGC North America

Nontargeted Metabolite Profiling in Next-Generation Plant Breeding: A Case Study in Malting Barley

December 01, 2015

MS–The Practical Art

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Non-targeted metabolite profiling by ultrahigh-performance liquid chromatography coupled with mass spectrometry (UHPLC–MS) is a powerful technique to investigate the influence of genetic and environmental influence on metabolic phenotype in plants. The approach offers an unbiased and in-depth analysis that can reveal molecular markers of desirable phenotypic traits which can be complementary to genetic markers in plant breeding efforts. Here, the power of non-targeted metabolite profiling is illustrated in a study focused on the determination of molecular markers in malting barley that are predictive of desirable malting quality for brewing applications.

The Ideal Chromatography Data System for a Regulated Laboratory, Part III: Essential Chromatographic Functions for Electronic Ways of Working

December 01, 2015

Peer Reviewed Article

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In the first two parts of this series we have looked at where and how a CDS fitted into a regulated laboratory and the overall requirements for the architecture of a future system. In this part we focus on new electronic ways of working for chromatographic analysis.

Preparing Eluents for HPLC—What You Ought to Know

December 01, 2015

The Essentials

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A short guide to the do’s, don’ts and gotcha’s of eluent preparation for everyday HPLC

Separation Science in Drug Development, Part IV: Quality Control

December 01, 2015

Perspectives in Modern HPLC

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This fourth and last installment in the series of “Separation Science in Drug Development” provides an overview of modern practices of Quality Control in small molecule drug development including activities such as setting specifications, method validation/transfer, release and stability testing, and authoring CMC sections of regulatory filings.

Future Needs of HPLC and UHPLC Column Technology

December 01, 2015

Column Watch

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In his final “Column Watch” article, Ron Majors looks into his crystal ball and discusses future needs in the area of HPLC/UHPLC column technology and related instrumentation. He looks at where current technology may be heading and makes a prediction that monolith-based columns may still have a rightful place in the HPLC/UHPLC laboratory .This article concludes his duration as a monthly columnist for LCGC.

Vol 33 No 12 LCGC North America December 2015 Regular Issue PDF

December 01, 2015

Issue PDF

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Click the title above to open the LCGC North America December 2015 regular issue, Vol 33 No 12, in an interactive PDF format.