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Special Issues-10-30-2010 | LCGC Supplements
Special Issues
Mass-Directed Preparative SFC: An Orthogonal Tool with Reduced Liquid Solvent Usage for High Throughput Purification
November 01, 2010
Application Note
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In recent years, improving productivity and cost-savings have become major initiatives in pharmaceutical discovery and development.
Comparison of Supercritical Fluid Extraction (SFE) and Pressurized Solvent Extraction (PSE) for the Recovery of gamma-Tocopherols in Walnut Oil
November 01, 2010
Articles
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Gamma-Tocopherol is the dominant form of Vitamin E in many commonly ingested foods in the human diet, such as plant seeds and nuts. In the past, supplement companies have focused on the health benefits of alpha-tocopherol.
Chiral Purification with Stacked Injections and Collections Using the Prep 100 SFC MS Directed System
November 01, 2010
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Chiral chromatography has become the preferred tool for enantiomer separations in the early stages of pharmaceutical development for the purpose of accurately identifying single pure enantiomers with pharmacologic, toxicological, and clinical information, as stipulated by the FDA.1
Basic Principles for Purification Using Supercritical Fluid Chromatography
November 01, 2010
Application Note
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Although supercritical fluid chromatography (SFC) is not a new technique, preparative SFC is becoming increasingly more popular with advances in instrumentation, software and chemistry.
Multi-Channel SFC System for Fast Chiral Method Development and Optimization
November 01, 2010
Articles
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According to the FDA policy statement, developing stereoisomeric drugs, each enantiomer should be evaluated.
Expediting Achiral SFC Method Development Using a Multi-Channel SFC System with MS Detection
November 01, 2010
Application Note
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In the past decade, supercritical fluid chromatography (SFC) has been established as a cost-effective, sustainable, and green purification technology for pharmaceutical and related industries.