Special Issues-10-30-2010

In recent years, improving productivity and cost-savings have become major initiatives in pharmaceutical discovery and development.

Gamma-Tocopherol is the dominant form of Vitamin E in many commonly ingested foods in the human diet, such as plant seeds and nuts. In the past, supplement companies have focused on the health benefits of alpha-tocopherol.

Chiral chromatography has become the preferred tool for enantiomer separations in the early stages of pharmaceutical development for the purpose of accurately identifying single pure enantiomers with pharmacologic, toxicological, and clinical information, as stipulated by the FDA.1

Although supercritical fluid chromatography (SFC) is not a new technique, preparative SFC is becoming increasingly more popular with advances in instrumentation, software and chemistry.

According to the FDA policy statement, developing stereoisomeric drugs, each enantiomer should be evaluated.

In the past decade, supercritical fluid chromatography (SFC) has been established as a cost-effective, sustainable, and green purification technology for pharmaceutical and related industries.