Addressing Chemical Diversity and Expanding Analytical Capabilities with Atmospheric Pressure GC
Atmospheric pressure gas chromatography is a technique that allows rapid switching between UPLC-MS and GC-MS applications.
Atmospheric pressure gas chromatography (APGC) is a technique that allows rapid switching between UPLC-MS and GC-MS applications. This provides laboratories with the flexibility to analyse volatile and semi-volatile compounds of low and intermediate polarity traditionally analysed by dedicated vacuum GC-MS instruments. Changeover of the electrospray source requires minimal tools, no breaking of vacuum and typically less than 5 minutes to perform. It is possible to acquire data in ESI+ using UPLC separation, then within 1 hour, review data acquired using APGC on the same instrument (assuming a typical GC run time of 25-30 min). This type of procedure can be particularly valuable when screening samples prepared using generic techniques such as QuEChERS, which can generate extracts amenable to both UPLC and GC separations.
TD-GC–MS and IDMS Sample Prep for CRM to Quantify Decabromodiphenyl Ether in Polystyrene Matrix
April 26th 2024At issue in this study was the certified value of decabromodiphenyl ether (BDE 209) in a polystyrene matrix CRM relative to its regulated value in the EU Restriction of Hazardous Substances Directive.
LC–MS/MS-Based System Used to Profile Ceramide Reactions to Diseases
April 26th 2024Scientists from the University of Córdoba in Córdoba, Spain recently used liquid chromatography–tandem mass spectrometry (LC–MS/MS) to comprehensively profile human ceramides to determine their reactions to diseases.
High-Throughput 4D TIMS Method Accelerates Lipidomics Analysis
April 25th 2024Ultrahigh-pressure liquid chromatography coupled to high-resolution mass spectrometry (UHPLC-HRMS) had been previously proposed for untargeted lipidomics analysis, but this updated approach was reported by the authors to reduce run time to 4 min.
Traditional Chinese Medicine’s Effects on Liver Cancer Measured Using New UHPLC–QTOF-MS System
April 22nd 2024Scientists from Anhui University of Chinese Medicine in Hefei, China recently investigated the mechanisms behind what makes huachansu tablets, a type of traditional Chinese medicine (TCM), effective against liver cancer.
