Targeted ultrahigh-performance liquid chromatography (UHPLC) links blood metabolites to sheep feed efficiency.
|Articles|June 7, 2010
- The Column-06-07-2010
- Volume 6
- Issue 10
Tips & Tricks: GPC/SEC Copolymer Analysis in GPC/SEC 1: Compositional Analysis by GPC/SEC with Multiple Detection
GPC/SEC analysis reveals a multitude of molar mass information about unknown samples that are chemically simple or homogenous.
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GPC/SEC analysis reveals a multitude of molar mass information about unknown samples that are chemically simple or homogenous.
However, results for copolymers may be compromised by the fact that fractions with different composition and different molar mass may co-elute.
There are different methods on how to characterize such samples:
• chemical composition analysis studied in GPC/SEC mode by concentration detectors (this issue)
• chemical heterogeneity analysis investigated by HPLC based on retention differences of samples with different composition (upcoming issue)
• comprehensive 2D analysis that allows samples to be separated by composition and molar mass simultaneously (upcoming issue)
This issue will discuss the chemical composition analysis with multiple detection, while the latter two will be discussed in the following two GPC/SEC: Tips & Tricks issues.
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