Advances in HPLC: An LCGC International Supplement
HPLC is being reinvented on every front—smaller, greener instrumentation; smarter, AI-assisted method development; next-generation column materials; and new approaches to age-old method challenges. This special supplement from LCGC International brings together leading voices in separation science to explore exactly where the field is headed, from capillary-scale systems built for sustainability to data tools that cut through messy LC–MS/MS data sets. Whether you're developing methods for complex biopharmaceuticals or just want to stay ahead of where liquid chromatography is going next, this supplement delivers the research and expert insight to keep you there.
Ultrahigh-performance liquid chromatography–tandem mass spectrometry (UHPLC–MS/MS) tracks blood metabolite changes after repetitive transcranial magnetic stimulation (rTMS)-cognitive training therapy.
Revisiting insertion distance for methanol and methylene chloride in GC analysis and confirming that insertion depth strongly affects response and reproducibility.
A novel SFC–QTOF-MS method accurately detected 10 drugs in oral fluid, matching LC–MS/MS in 83 DUID cases while reducing run time by 42% and organic solvent use by 81%.
Supercritical fluid extraction (SFE) and high-pressure liquid chromatography (HPLC) team up to recover olive waste antioxidants. Marina Russo of the University of Messina (Italy) discusses the details.
Waters' Erin Chambers says combining column chemistry and particle-physics innovation cut a GLP-1 impurity profiling workflow from three hours to under one.