Applying Analytical Method Greenness Scoring to the USP Monograph of Naproxen; Improving the Sustainability of Validated Methods by Modernizing to Newer Technology

In this application note the USP monograph method for naproxen sodium tablets was modernized and Analytical Method Greenness Scoring (AMGS) values were assigned to each system used. The use of newer technology including sub-2 µm columns provides not only improvements to throughput and solvent usage but also drastically improved AMGS values.