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September 29th, 2026

Chromatography Detects Toxins in Tea Samples

High-performance liquid chromatography-tandem mass spectroscopy (HPLC–MS/MS) chromatography reveals pyrrolizidine alkaloids (PA)/pyrrolizidine alkaloid N-oxides (PANO) toxin risks in 63 tea samples.

Coronavirus Covid-19 background - 3d rendering | Image Credit: © Production Perig - stock.adobe.com.

September 29th, 2026

DNA and RNA Chromatography: Enabling mRNA Vaccine Validation

Advances in DNA/RNA chromatography columns led to stable, pure mRNA production, supporting the development of COVID-19 vaccines rapidly.

September 29th, 2026

The Route to Scaling Organoid LC–MS

Steven Ray Wilson's AFFL LC–MS system runs thousands of injections per column, but he calls validation and standardization the field's real barrier.

Woman in science set or female scientist in laboratory tiny person collection | Image Credit: © VectorMine - stock.adobe.com.

September 29th, 2026

Women in Chromatography: Confronting Imposter Syndrome in STEM

Kinjal Bhatt and Ina Varfaj describe imposter syndrome fading through repeated exposure and conference talk rather than a single breakthrough moment.

Figure 1. Overview of the idea of MS as a tool for teaching chemistry ideas across the curriculum, with examples for general chemistry, organic chemistry, biochemistry, and physical chemistry.

September 28th, 2026

Teaching Chemical Concepts Through the Lens of Mass Spectrometry

Mass spectrometry can teach core chemistry concepts beyond technique training or product characterization, though adoption barriers remain.

Figure 3. Comparison of the production method using a volcano plot. Volcano plots highlight features that differ significantly between groups by plotting the magnitude of change vs. statistical significance, making it easy to spot the most important differences.

September 28th, 2026

Beyond Conventional GC–MS: Revealing Hidden Food Differences

Automated sequential tube sampling and chemometrics supplement GC–MS, adding time profiling and fast product-line comparison for real-world insight.

September 28th, 2026

LC–MS Reveals Metabolic Shifts in Alzheimer's Disease

Ultrahigh-performance liquid chromatography–tandem mass spectrometry (UHPLC–MS/MS) tracks blood metabolite changes after repetitive transcranial magnetic stimulation (rTMS)-cognitive training therapy.

Figure 2. Split injection used to measure triplicate test of MTBE, hexane, o-xylene, and 1-methylnaphthalene comparing different solvents (methanol, methylene chloride) and column insertion distances starting with 0.5 mm, 5.0 mm, 10.0 mm, 15 mm, and 20.0 mm. Methanol had the best performance at the 5.0 mm insertion distance and methylene chloride looked slightly better at the 0.5 mm. We would still recommend not going below the 5.0 mm manufacturer recommended insertion distance.

September 28th, 2026

Revisiting Column Insertion Distance

Revisiting insertion distance for methanol and methylene chloride in GC analysis and confirming that insertion depth strongly affects response and reproducibility.

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