CE-MS and Coronary Artery Disease Diagnosis

Researchers from Germany, Belgium, the UK, and Australia conducted a study of urine from patients with and without coronary artery disease to look for proteome patterns indicative of the disease.

Researchers from Germany, Belgium, the UK, and Australia conducted a study of urine from patients with and without coronary artery disease to look for proteome patterns indicative of the disease. They used capillary electrophoresis coupled with mass spectrometry (CE–MS) to analyze the urine samples. They examined a combination of 17 polypeptides and found specific polypeptide patterns in the urine that were associated with coronary artery disease in patients with angina. They suggest that further studies are necessary to evaluate the clinical value of the CE–MS urine proteome analysis for diagnosis of coronary artery disease.