This article will demonstrate the feasibility of analysing complex mixtures without any prior sample preparation by making use of the high resolving power of both UHPLC and mass spectrometry.
Red wine is a very complex mixture and a rich source of beneficial anti-oxidants. Identification and quantification of these natural products is challenging. Ultra-high pressure liquid chromatography (U-HPLC) coupled to a mass spectrometer is used for the analysis of French red wine, enabling simultaneous detection and relative quantification of the wine’s antioxidant constituents. Using this technique, the phenolic compounds (such as quercetin) responsible for most of the health benefits associated with the consumption of red wine can be identified and their variable content across two different harvest years can be observed. Direct wine analysis approach is then applied to monitor the progressive changes in red wine after its exposure to air. The successful use of this approach has meant metabolomic analysis has become a rapidly growing area of interest in nutrition and health research. This article will demonstrate the feasibility of analysing complex mixtures without any prior sample preparation by making use of the high resolving power of both U-HPLC and mass spectrometry
Analytical Challenges in Measuring Migration from Food Contact Materials
November 2nd 2015Food contact materials contain low molecular weight additives and processing aids which can migrate into foods leading to trace levels of contamination. Food safety is ensured through regulations, comprising compositional controls and migration limits, which present a significant analytical challenge to the food industry to ensure compliance and demonstrate due diligence. Of the various analytical approaches, LC-MS/MS has proved to be an essential tool in monitoring migration of target compounds into foods, and more sophisticated approaches such as LC-high resolution MS (Orbitrap) are being increasingly used for untargeted analysis to monitor non-intentionally added substances. This podcast will provide an overview to this area, illustrated with various applications showing current approaches being employed.
Best of the Week: What’s New in MS, 2024 Young Chemist Award Winner
March 22nd 2024This week, LCGC International published a variety of articles on the hottest topics in chromatography and beyond. Below, we’ve highlighted some of the most popular articles, according to our readers. Happy reading!
Inside the Laboratory: The Schug Group at the University of Texas at Arlington
March 22nd 2024In this edition of “Inside the Laboratory,” Kevin Schug, PhD, a full professor of chemistry at the University of Texas at Arlington, discusses his laboratory’s group work in environmental monitoring around water and soil quality near oil and gas extraction, using techniques such as liquid chromatography (LC), gas chromatography (GC), supercritical fluid chromatography (SFC), and coupling these techniques with mass spectrometry (MS).
Cloruson and Related Substances Studied Using Original Ion-Pair UHPLC Method
March 19th 2024In a recent study out of Boehringer Ingelheim Animal Health USA Inc. in North Brunswick, New Jersey, scientists investigated cloruson and its related substances using an original ion-paired reversed phase ultraperformance liquid chromatography (IP-UHPLC) method.