GC-MS Used to Determine Effects of High Fat Diet During Pregnancy
Researchers from the University of Utah (Salt Lake City, Utah) and the Oregon National Primate Research Center (Beaverton, Oregon) used gas chromatography-mass spectrometry based metabolomics to analyze blood from mothers and offspring of animals fed a high fat diet.
Researchers from the University of Utah (Salt Lake City, Utah) and the Oregon National Primate Research Center (Beaverton, Oregon) used gas chromatography–mass spectrometry based metabolomics to analyze blood from mothers and offspring of animals fed a high fat diet. They found that a high fat diet during pregnancy results in offspring with fatty livers and causes changes in the small molecules that govern metabolism, including fatty acids and amino acids most likely to affect energy use and fat storage. The study was led by a research group at Baylor College of Medicine (Houston, Texas). In their study, they compared three groups: mothers fed a 13% fat control diet and their offspring, mothers fed a 35% fat diet and their offspring, and mothers who were obese but on a control diet during pregnancy and their offspring. The metabolomic footprint included more than 1300 chromatographic features.
Linking LC-HRMS Features to Aquatic Toxicity: A Nontargeted Approach Without Compound Identification
July 7th 2025A recent study conducted by the University of Amsterdam (Amsterdam, Netherlands) and the University of Queensland (Queensland, Australia) developed a novel prioritization strategy that directly links fragmentation and chromatographic data to aquatic toxicity categories, bypassing the need for identification of individual compounds. LCGC International spoke to Viktoriia Turkina of the University of Amsterdam, lead author of the paper that resulted from this study, about their work.
Detection and Risk Assessment of Mycotoxins in Commercial Tortillas Using HPLC-Based Methods
July 4th 2025A joint study between Selçuk University (Konya, Turkey) and Hitit University (Corum, Turkey) determined the natural occurrence and concentrations of the mycotoxins ochratoxin A (OTA) and deoxynivalenol (DON) in commercially available tortillas in Turkey. Contamination levels were quantified using validated analytical methods based on high-performance liquid chromatography (HPLC) coupled with fluorescence or ultraviolet detectors (HPLC-FLD or HPLC–UV).
