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News|Articles|August 26, 2023

New Approaches to Comparing Multidimensional GC–MS Chromatograms

Author(s)LCGC Staff

As part of an upcoming meeting on Recent Advances in Gas Chromatography meeting, led by Tony Taylor and Dan Carrier, one of the many talks planned will focus on how workflows for comparing 1D and 2D GC–MS chromatograms can be automated.

The talk, "From Data to Decisions: Automated Workflows for Comparing 1D and 2D GC-MS Chromatograms", will be led by Laura McGregor of SepSolve, of Peterborough, UK. Its subject will appeal to experienced and new chromatographers alike, broadening their knowledge and helping them look at these techniques in new ways.

To learn more about this workshop and others, you can register for more information at https://na.eventscloud.com/ereg/index.php?eventid=743617 or contact registration@sasevents.co.uk .


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Figure 2. Split injection used to measure triplicate test of MTBE, hexane, o-xylene, and 1-methylnaphthalene comparing different solvents (methanol, methylene chloride) and column insertion distances starting with 0.5 mm, 5.0 mm, 10.0 mm, 15 mm, and 20.0 mm. Methanol had the best performance at the 5.0 mm insertion distance and methylene chloride looked slightly better at the 0.5 mm. We would still recommend not going below the 5.0 mm manufacturer recommended insertion distance.
Revisiting insertion distance for methanol and methylene chloride in GC analysis and confirming that insertion depth strongly affects response and reproducibility.