|Articles|December 1, 2022

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Pharma 4.0 and the Digital Regulated Laboratory Part 3: Quick Wins and Implementing Projects

This is the final in a series of three eBooks discussing and offering practical advice on the journey from current ways of working to a digital laboratory operating in a regulated environment. Learn more about:


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Figure 2. Split injection used to measure triplicate test of MTBE, hexane, o-xylene, and 1-methylnaphthalene comparing different solvents (methanol, methylene chloride) and column insertion distances starting with 0.5 mm, 5.0 mm, 10.0 mm, 15 mm, and 20.0 mm. Methanol had the best performance at the 5.0 mm insertion distance and methylene chloride looked slightly better at the 0.5 mm. We would still recommend not going below the 5.0 mm manufacturer recommended insertion distance.
Revisiting insertion distance for methanol and methylene chloride in GC analysis and confirming that insertion depth strongly affects response and reproducibility.
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