Join the global community of analytical scientists who trust LCGC for insights on the latest techniques, trends, and expert solutions in chromatography.

Related to this article

Figure 3. Comparison of the production method using a volcano plot. Volcano plots highlight features that differ significantly between groups by plotting the magnitude of change vs. statistical significance, making it easy to spot the most important differences.

September 28th, 2026

Beyond Conventional GC–MS: Revealing Hidden Food Differences

Automated sequential tube sampling and chemometrics supplement GC–MS, adding time profiling and fast product-line comparison for real-world insight.

Figure 2. Split injection used to measure triplicate test of MTBE, hexane, o-xylene, and 1-methylnaphthalene comparing different solvents (methanol, methylene chloride) and column insertion distances starting with 0.5 mm, 5.0 mm, 10.0 mm, 15 mm, and 20.0 mm. Methanol had the best performance at the 5.0 mm insertion distance and methylene chloride looked slightly better at the 0.5 mm. We would still recommend not going below the 5.0 mm manufacturer recommended insertion distance.

September 28th, 2026

Revisiting Column Insertion Distance

Revisiting insertion distance for methanol and methylene chloride in GC analysis and confirming that insertion depth strongly affects response and reproducibility.

Preventing Detector Problems

Articles in this issue

Related to this article

Trending on LCGC International

HPLC Method Measures Fiber's Cholesterol Uptake

The LCGC Blog: NIST Reference Materials

Challenges and Solutions in Oligonucleotide Analysis, Part V: Troubles with Phosphorothioate Oligonucleotides

Women in Chromatography: Being the Only Woman in the Room

Untangling Closely Eluting and Isobaric Impurities in GLP-1 Peptides