Protein Standards Increase HPLC Accuracy
A newly launched library of more than 5,000 human proteins is desinged for increased accuracy in high performance liquid chromatography and mass spectrometry analyses, according to life sciences company OriGene Technologies.
A newly launched library of more than 5,000 human proteins is desinged for increased accuracy in high performance liquid chromatography and mass spectrometry analyses, according to life sciences company OriGene Technologies.
The company has released a library of heavy isotope labelled human proteins to serve as international standards for mass spectrometry analyses featuring single reaction and multiple reaction monitoring (MRM). According to the company, the aim is to produce research tools that allow for disease mechanisms to be researched and drugs to be developed based across the entire human genome, with stem cell research and cancer as two areas of particular interest.
“Mass spectrometry - especially MRM - has emerged as a new platform for quantitative characterisation of multiple proteins, thus making it an ideal choice for high-throughput proteomics and clinical biomarker research,” the company stated in a press release.
Modern HPLC Strategies: Improving Retention and Peak Shape for Basic Analytes
August 16th 2024In high-performance liquid chromatography (HPLC), it is common for bases and unreacted ionized silanols on silica-based columns to cause irreproducible retention, broad peaks, and peak tailing when working with basic analytes. David S. Bell, Lead Consultant at ASKkPrime LLC offers innovative HPLC strategies that can help mitigate such issues.
