Quantifying drug impurities: reference Standards vs RRFs

Quantitative non-targeted screening with predicted response factors is not for regulation, but can rank environmental chemicals by concentration and toxicity.

Gert Desmet explores the current role of AI/ML in separation science.

Gas chromatography–mass spectrometry (GC–MS) reveals a four-stage polycyclic aromatic hydrocarbons (PAH) breakdown in oil sludge co-composted with manure.

This new high-performance liquid chromatography-ultraviolet (HPLC-UV) method measures glutathione and thiol levels across 12 berries.

Piotr Alvarez explains how HILIC complements reversed-phase LC for GLP-1 peptides, and why the field is moving toward MS-friendly TFA alternatives.

In this third part of " Conversations with Michael Dong," a series on fundamentals of HPLC in pharmaceutical analysis, LCGC International’s "Perspectives in HPLC" column editor discusses the retention mechanism of hydrophobic interaction.

Liquid chromatography–tandem mass spectrometry (LC–MS/MS) shows hydrogel cuts dogs' peak bupivacaine blood levels fivefold.

In the second part of our interview, Novartis's Martina Lioi talks about using IP-HILIC and RP for lipid-siRNA impurities