News|Articles|January 29, 2026

Rapid and Sensitive Determination of Haloacetic Acids and Acrylamide in Drinking Water using LC-Triple Quadrupole Mass Spectrometry

Haloacetic Acids (HAAs) and acrylamide are introduced into the drinking water supply during different stages of the water treatment process. HAAs are formed as unwanted disinfection by-products (DBPs) when chlorine is added to waters sources to kill pathogens whilst acrylamide is indirectly introduced via the use of polyacrylamide as a flocculant during water treatment.
Both compound classes are carcinogenic, whilst acrylamide is also known to also be mutagenic, and reprotoxic, thus requiring their levels in drinking water to be strictly measured. 
Here we describe how the Agilent LC-Triple Quadrupole mass spectrometers are able to simultaneously quantify these compounds to meet the requirements of the (EU) 2020/2184 directive.

This webinar also examines the challenges and implications of PFAS testing for water suppliers and regulatory bodies detailing best practices for sustained analytical performance. Key aspects include the implementation of liquid chromatography-tandem mass spectrometry (LC-MS/MS), the establishment of maximum allowable concentrations, and the periodic review of PFAS limits based on emerging scientific evidence. We describe the use of PFAS free LC kits and enhancements to standard LC configurations to minimize contamination delivering accurate and precise results at the lowest mandated concentration levels.

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