Researchers Develop New Method for Drug Testing
US researchers have developed a new LC-MS-MS method of detecting if athletes have taken drugs to artificially boost testosterone and increase physical performance.
US researchers have developed a new LC-MS-MS method that is more senstive for detecting if athletes have taken drugs to artificially boost testosterone and increase physical performance. Previous testing methods used GC-MS to compare the ratio of testosterone to epitestosterone and determine if performance enhancing drugs were taken. However, measuring the T/E concentrations is difficult due to the low levels present in urine.
According to the lead researcher, Dr Jonathan Danaceau of the University of Utah, the new method "means that we can determine the T/E ratio in a sample with greater confidence, and therefore be in a better position to spot doping violations without falsely accusing innocent athletes."
Fundamentals of Benchtop GC–MS Data Analysis and Terminology
April 5th 2025In this installment, we will review the fundamental terminology and data analysis principles in benchtop GC–MS. We will compare the three modes of analysis—full scan, extracted ion chromatograms, and selected ion monitoring—and see how each is used for quantitative and quantitative analysis.
Characterizing Plant Polysaccharides Using Size-Exclusion Chromatography
April 4th 2025With green chemistry becoming more standardized, Leena Pitkänen of Aalto University analyzed how useful size-exclusion chromatography (SEC) and asymmetric flow field-flow fractionation (AF4) could be in characterizing plant polysaccharides.
This information is supplementary to the article “Accelerating Monoclonal Antibody Quality Control: The Role of LC–MS in Upstream Bioprocessing”, which was published in the May 2025 issue of Current Trends in Mass Spectrometry.
