Key Points:
- The ZenoTOF 8600 includes technical upgrades such as the OptiFlow Pro source, advanced ion guides, and a new optical detector to improve sensitivity and support higher ion currents.
- The updated ZT Scan DIA 2.0 technology expands the mass range, allowing for better detection of a broader variety of molecules in proteomics, metabolomics, and other omics applications.
- Sciex released OS software version 4.0 which improves automation and processing speeds.
- The company reaffirmed its partnership with Evosep to co-market integrated mass spectrometry and UHPLC solutions aimed at streamlining proteomics workflows.
At this week’s American Society for Mass Spectrometry (ASMS) Conference in Baltimore, Maryland, Sciex presented updates to its mass spectrometry product lineup, focusing on tools for quantitative analysis in omics research.
The main announcement was the ZenoTOF 8600 system, a mass spectrometer designed to provide rapid, high-resolution analysis of thousands of molecular species in complex biological samples. The system targets applications across proteomics, metabolomics, and genomics.
“We have had units out for the last six months to get their feedback and understand the end point application,” said Chris Lock, vice president of Global R&D at Sciex. “We work closely with the scientists working in the lab there and explore the capabilities able to make tweaks with the system.”
Sciex reported that the ZenoTOF 8600 offers up to a tenfold increase in sensitivity compared to its predecessor. This improvement comes from technical changes such as the OptiFlow Pro source, upgraded ion guides (DJet and QJet), and a new optical detector capable of handling higher ion currents.
The system also incorporates updated ZT Scan DIA 2.0 technology, which expands the mass range available for quantification and aims to address detection challenges in some omics applications. Mass Guard technology is included to reduce downtime caused by contamination, a concern in high-throughput laboratories.
Sciex also reiterated its partnership with Evosep, a company specializing in protein-based clinical instruments. Since 2021, Sciex and Evosep have worked together to co-market mass spectrometry systems combined with ultra-high-performance liquid chromatography (UHPLC) separation technologies, with the goal of providing more integrated proteomics platforms.
Instrument Development Driven by Omics Research
Omics research remains a key force shaping the development of mass spectrometry technologies, as it demands increasingly sophisticated tools to analyze complex biological systems. At the ASMS conference, many vendors highlighted advancements focused on improving both sensitivity and throughput, recognizing that researchers need instruments capable of detecting low-abundance molecules while handling large numbers of samples efficiently. These requirements stem from the complexity and diversity of omics datasets, which include proteomics, metabolomics, genomics, and lipidomics, each with unique analytical challenges.
To keep pace, mass spectrometers must deliver high-resolution, accurate data rapidly, enabling scientists to generate comprehensive profiles without compromising data quality or reproducibility. This balance between speed and precision is critical for accelerating discovery and translating findings into practical applications such as biomarker identification, drug development, and personalized medicine.
Precision is especially important, Lock noted, as laboratories face increasing pressure to process larger volumes of samples in shorter timeframes without compromising analytical quality. This need becomes even more critical for labs working with limited or hard-to-obtain sample quantities, where accuracy must be maintained despite constraints.
“In forensics, you don’t get to get another sample,” Lock said. “I think that has been a significant evolution in the field, the ability to retrospectively go back and interrogate.”
Improving Analysis Through Software Innovation
Beyond hardware, Sciex emphasized its ongoing efforts to deliver data analysis solutions. To handle the increased data volumes generated by the ZenoTOF 8600, the company launched OS software version 4.0, with improved automation and faster processing speeds. Sciex also highlighted its expanded software portfolio, emphasizing new integrations to support more advanced data analysis across omics workflows.
The company also reported ongoing work with MS-Dial to support metabolomics and lipidomics analysis, particularly in improving spectral deconvolution and compound identification. Its integration with Bioinformatics Solutions’ PEAKS Studio 13 is intended to extend proteomics capabilities, with a focus on analyzing post-translational modifications, sequence variants, and peptide-level detail.
Lock expressed optimism about the role of tools like artificial intelligence (AI) and automation in advancing data analysis but emphasized that their effectiveness depends on the availability of high-quality input data.
“I think we’re really excited about the potential,” he said. “But it’s never going to replace the scientist doing the review.”
