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|Articles|June 1, 2000

LCGC North America

  • June 2000
  • Volume 18
  • Issue 06
  • Pages: 610–618

Strategies for GC Optimization, Part II - Columns

In this month's "GC Connections," John Hinshaw examines optimization strategies for gas chromatography columns in the second installment of a multipart series. He starts with a question from a reader and then discusses broader column issues.

LCGC 18(6), 610–618 (2000).

Articles in this issue

over 26 years ago

Regulatory Review of Method Validation Protocols

over 26 years ago

Coupling Chiral Stationary Phases as a Fast Screening Approach for HPLC Method Development

over 26 years ago

Stainless Steel Surfaces in LC Systems, Part I – Corrosion and Erosion

over 26 years ago

Advances in the Design of HPLC Packings

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Figure 2. Split injection used to measure triplicate test of MTBE, hexane, o-xylene, and 1-methylnaphthalene comparing different solvents (methanol, methylene chloride) and column insertion distances starting with 0.5 mm, 5.0 mm, 10.0 mm, 15 mm, and 20.0 mm. Methanol had the best performance at the 5.0 mm insertion distance and methylene chloride looked slightly better at the 0.5 mm. We would still recommend not going below the 5.0 mm manufacturer recommended insertion distance.
Revisiting Column Insertion Distance
Revisiting insertion distance for methanol and methylene chloride in GC analysis and confirming that insertion depth strongly affects response and reproducibility.
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