Lorna De Leoz, Agilent Global Food Segment Director, addresses the growing concern surrounding per- and polyfluoroalkyl substances (PFAS) in food supply. These “forever chemicals” accumulate in the environment and in people, and are associated with serious health risks including cancer and immune suppression. PFAS are notoriously difficult to detect and remove because they originate from multiple sources (water, soil, packaging) and encompass nearly 15,000 individual compounds. Because of their pervasive nature, laboratories must meet extremely low detection limits, meaning robust analytical testing is essential to managing exposure. Agilent is helping the industry address these challenges with simplified, scalable, end-to-end testing solutions, such as pass-through cleanup workflows and clean components, that reduce contamination risk and help laboratories stay ahead of regulatory demands.
This LCGC Blog installment explains how NIST categorizes and certifies reference materials, and why they underpin reliable results in science and medicine.
Comparing manual and automated N-glycan profiling of a trastuzumab biosimilar, researchers found that both workflows detected the same glycan types, but automation gave more reproducible results (mean CV of about 5.7% vs. 7.95%), making it better suited to high-throughput analysis in biopharmaceutical development.
Malte Hübschen of the University of Duisburg-Essen (Germany) discusses an automated gas chromatography-tandem mass spectrometry (GC-MS/MS) workflow that improves phthalate detection in tricky oils with LCGC International.