Liquid chromatography-tandem mass spectrometry (LC-MS/MS) finds high fentanyl levels do not predict toxicity in tolerant users.
|Articles|July 18, 2012
- The Column-07-18-2012
- Volume 8
- Issue 13
Understanding the Behaviour of Pharmaceutical Polymers
Author(s)Greg D. Saunders
This article discusses GPC and gives examples of the use of the technique in excipient analysis.
New philosophies in pharmaceutical industry such as Quality by Design (QbD) require a detailed understanding of the properties and behaviour of drug components, including polymeric excipients such as binders and disintegrants. Gel permeation chromatography (GPC, also known as size exclusion chromatography) is a vital tool for investigating the behaviour of polymers, and is increasingly employed in pharmaceutical laboratories to investigate macromolecules. This article discusses GPC and gives examples of the use of the technique in excipient analysis.
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