Understanding the Behaviour of Pharmaceutical Polymers

Article

The Column

ColumnThe Column-07-18-2012
Volume 8
Issue 13
Pages: 13–17

This article discusses GPC and gives examples of the use of the technique in excipient analysis.

New philosophies in pharmaceutical industry such as Quality by Design (QbD) require a detailed understanding of the properties and behaviour of drug components, including polymeric excipients such as binders and disintegrants. Gel permeation chromatography (GPC, also known as size exclusion chromatography) is a vital tool for investigating the behaviour of polymers, and is increasingly employed in pharmaceutical laboratories to investigate macromolecules. This article discusses GPC and gives examples of the use of the technique in excipient analysis.

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Understanding the Behaviour of Pharmaceutical Polymers
Understanding the Behaviour of Pharmaceutical Polymers
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