Vol 29 No 8 LCGC North America August 2011 Regular Issue PDF

High-performance liquid chromatography (HPLC) was recently used to detect acylated impurities in artificial hormones meant to treat prostate cancer symptoms.

Cell membrane chromatography (CMC) technology was used by researchers in screening efficacy and antibacterial ability of articaine (AT) derivatives in the pre-emptive treatment of oral infections.

Two proof-of-concept hydrophilic interaction chromatography HILIC) methods were developed in a joint study conducted by the University of Geneva (Switzerland), Sanofi, and the Waters Corporation—one for disrupting LNPs and retaining the mRNA, and another for detecting only unencapsulated mRNA to assess encapsulation efficiency. LCGC International spoke to Jonathan Maurer, first author of the paper that resulted from this study, about the methods and the efforts that led up to their development.

This article discusses how integrating seven prioritization strategies can enhance compound identification, support environmental risk assessment, and accelerate decision-making.