Vol 31 No s4 LCGC North America April 2013 Recent Developments in HPLC and UHPLC Supplement PDF

Panelists identify the parameters that make or break peptide method robustness and tech transfer, including temperature, flow rate, and dwell volume.

In Part 2 of "Conversations with Michael Dong," the LCGC column editor discusses HPLC columns for pharmaceutical analysis and the case for short columns.

Gas chromatography-mass spectrometry (GC–MS) shows scarlet macaw feather scent varies by sex and mate status.

Martina Lioi pairs IP-HILIC and RP to map impurities in fatty acid–linked siRNAs

Gas chromatography-mass spectrometry (GC–MS) reveals bisphenol A and other lasting pollutants in Maricá Lagoon (Brazil) sediments.

This week, Chromatography Online covered automated GC-MS/MS testing for phthalates in oils, chemicals hidden in bioplastic packaging, troubleshooting tips for oligonucleotides and GLP-1 peptides, automated glycan profiling, NIST reference materials, and the experience of being the only woman in the laboratory.

Multidimensional chromatography cuts ion suppression in complex environmental samples by separating salts and coeluting compounds from target analytes.

The panel discusses quantitative peptide analysis, including drug substance vs. drug product complexity, recovery, and methionine oxidation risk.