Bonnie A. Alden

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Modifying the Metal Surfaces in HPLC Systems and Columns to Prevent Analyte Adsorption and Other Deleterious Effects

Modifying the Metal Surfaces in HPLC Systems and Columns to Prevent Analyte Adsorption and Other Deleterious Effects

Thomas H. Walter;Bonnie A. Alden;Jonathan L. Belanger;Kenneth Berthelette;Cheryl Boissel;Mathew DeLano;Lavelay Kizekai;Jennifer M. Nguyen;Stephen J. Shiner
June 1st 2022

A novel surface modification technology has been developed to reduce interactions between analytes and metal surfaces in HPLC instruments and columns. We demonstrate the impact of this technology on peak symmetry, peak area, and injection-to-injection and column-to-column reproducibility for several metal-sensitive analytes.

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