Jelena Petrovic | Authors


Analysis of Boronic Compounds as Potential Mutagenic Impurities in Drug Substances By GC–MS

This novel gas chromatography (GC)–MS approach enables analysis of the suspected mutagens bis(pinacolato)diboron (BPD) and tetrahydroxydiboron (BBA) found at low-levels in certain intermediates and active pharmaceutical ingredients (APIs), even in the presence of boron from other sources.