Jelle De Vos

home / authors / jelle-de-vos

Articles

Hand with Pen Proofreading | Image Credit: © damark - stock.adobe.com

Pushing Boundries

Valentina D'Atri;Jelle De Vos

December 1st 2023

An introduction from our guest editors.

Reed Harris retired in 2022 after a 39-year career in biotechnology, starting as a research assistant and finishing as a senior staff scientist in the Roche-Genentech Pharma Technical Development department, with strategic, review, and teaching responsibilities. His former roles includ: Head of Investigational Medicinal Product Quality for Roche, senior director of Analytical Development & QC, analytical characterization scientist for Herceptin and Xolair, and head of a protein structure lab. He was the global (Genentech + Novartis) Xolair technical development team leader from Phase 2 through licensing. Reed is a CASSS Distinguished Fellow and has been an author of 49 publications, including 14 as corresponding author. He was a leader in the development of Roche-Genentech’s strategies for post-approval comparability exercises, clinical and commercial specifications, the identification of critical quality attributes, linking structure to function, the use of a risk-based Quality by Design approach for control strategy development, unexpected protein modification identification, and curiosity-based thinking.

Critical Thinking On Characterization

Valentina D'Atri;Jelle De Vos

December 1st 2023

An interview with Reed Harris on critical quality attributes and other contemporary trends in biopharm analysis.

Particles, Pressure, and System Contribution: The Holy Trinity of Ultrahigh-Performance Liquid Chromatography

Ken Broeckhoven;Jelle De Vos;Gert Desmet

March 1st 2018

The last decade has witnessed how liquid chromatography columns and instruments changed from long bulky columns with relatively large fully porous particles operated at modest pressures (100Ð200 bar), to short compact columns with small superficially porous particles operated at ultrahigh pressures (1200Ð1500 bar). This (r)evolution has resulted in a tremendous increase in achievable separation performance or decrease in analysis time, but requires a good knowledge of optimal chromatographic conditions for each separation problem and, concomitant, the right instrument configuration.

Pressure, Particles, and System Contribution: The Holy Trinity of Ultrahigh-Performance Liquid Chromatography

Ken Broeckhoven;Jelle De Vos;Gert Desmet

November 1st 2017

The last decade has witnessed how liquid chromatography columns and instruments changed from long bulky columns with relatively large fully porous particles operated at modest pressures (100–200 bar), to short compact columns with small superficially porous particles operated at ultrahigh pressures (1200–1500 bar). This (r)evolution has resulted in a tremendous increase in achievable separation performance or decrease in analysis time, but requires a good knowledge of optimal chromatographic conditions for each separation problem and, concomitant, the right instrument configuration.