Katianna A. Pihakari | Authors

Katianna A. Pihakari is with Varian FTMS Systems, Lake Forest, California.


FT–MS to Provide Novel Insight into Complex Samples

More than 20 years passed after the introduction of Fourier transform–ion cyclotron resonance mass spectrometry (FT-MS) before advancements in electronics and computer technology enabled the development of practical, high-performance instruments. Modern analytical FT-MS instruments rely on sophisticated electronic circuitry and powerful computer software to achieve the dramatic resolving power and mass accuracy typical for the instrumentation. Here, the power of modern hybrid FT-MS instrumentation is discussed by demonstrating the capability of this instrumentation for selected applications such as the analysis of crude oil, intact protein, and fragile noncovalent complex samples.