Lloyd R. Snyder | Authors

How do non-alkylsilica columns provide us an additional dimension of column selectivity?

How do non-alkylsilica columns provide us an additional dimension of column selectivity?

When developing or modifying an LC separation, a common strategy is to change selectivity by choosing a new column. Here’s guidance for making that selection.

Reversed-phase liquid chromatographic columns can be compared quantitatively for differences in selectivity by means of the hydrophobic-subtraction model. This allows selection of columns that are either equivalent or different in selectivity. The present paper both presents a summary of this approach and shows in detail how to use it in practice.

A pioneer in high performance liquid chromatography reflects on his career and how "enlightened trial-and-error" can reduce the effort involved in method development.

A pioneer in high performance liquid chromatography reflects on his career and how "enlightened trial-and-error" can reduce the effort involved in method development.