Lloyd R. Snyder | Authors


The Hydrophobic-Subtraction Model for Reversed-Phase Liquid Chromatography: A Reprise

Reversed-phase liquid chromatographic columns can be compared quantitatively for differences in selectivity by means of the hydrophobic-subtraction model. This allows selection of columns that are either equivalent or different in selectivity. The present paper both presents a summary of this approach and shows in detail how to use it in practice.

Efficient HPLC Method Development and Personal Reflections

A pioneer in high performance liquid chromatography reflects on his career and how "enlightened trial-and-error" can reduce the effort involved in method development.