Masashi Serizawa and Andrea Gargano, researchers at the Van ‘t Hoff Institute for Molecular Sciences (HIMS, University of Amsterdam) sit down with LCGC International to discuss how reversed-phase liquid chromatography and high-resolution mass spectrometry (RPLC-HRMS) analysis of degraded PLGA oligomers reveals block-length differences behind solubility variation in copolymers.