Andrea Gargano | Authors


Supercritical Fluid Chromatography for Chiral Analysis, Part 2: Applications

In the second part of this review article, the recent progress in SFC for enantiomeric separations is evaluated. Several applications reported on the enantioselective separation of drugs and pharmaceutical compounds using chiral SFC are discussed, including pharmaceutical applications, clinical research, forensic toxicology, and environmental sciences.

Supercritical Fluid Chromatography for Chiral Analysis, Part 1: Theoretical Background

With the substantial developments carried out over the past years in instrumentation, columns, and detector hyphenation, the interest in chiral supercritical fluid chromatography (SFC) has been steadily growing in various fields. In the first part of this review article, the theoretical advantages, technological developments, and common practices in chiral SFC are discussed.

Clinical Metabolomics: Expanding the Metabolome Coverage Using Advanced Analytical Techniques

This review article discusses the novel separation and detection strategies that are considered promising in clinical metabolomics to enhance the metabolome coverage. It includes hydrophilic interaction chromatography (HILIC), supercritical fluid chromatography (SFC), multidimensional LC approaches, as well as ion-mobility mass spectrometry (IM-MS) and data-independent acquisition (DIA) analysis methods.

Enantiomer and Topoisomer Separation of Acidic Compounds on Anion-Exchanger Chiral Stationary Phases by HPLC and SFC

Quinine- and quinidine-derived anion-exchanger chiral stationary phases have proven to be versatile in enantiomer separation of acidic compounds in HPLC. In this article, the authors demonstrate their performance in specific HPLC applications involving enantiomer resolution and topoisomer separation.