Michael Lämmerhofer

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Articles

Untargeted LC–MS Lipidomics with Data Independent Acquisition using Sequential Window Acquisition of All Theoretical Fragment-Ion Spectra

Bernhard Drotleff;Carlos Calderón Castro;Malgorzata Cebo;Kristina Dittrich;Xiaoqing Fu;Michael Lämmerhofer

January 1st 2021

A focus on untargeted UHPLC–MS/MS lipidomics with data independent acquisition using SWATH technology. This article explores the wide-ranging potential and peculiarities of SWATH–MS hyphenated with UHPLC for the profiling of lipidomes of various biological samples.

Peptide Analysis: Zwitterionic Chiral Ion-Exchangers as Complementary Option to HILIC and to Reversed-Phase Chromatography

Wolfgang Lindner;Pilar Franco;Michael Lämmerhofer;Adrian Sievers-Engler;Harald Gross;Emilie Holder;Heike Gerhardt;Tony Zhang

March 1st 2016

Therapeutic peptides represent one of the fastest growing segments in the pharmaceutical market. To bring these products to the market in a consistent manner, high quality is a major concern and requires stringent quality control (QC) methods. This article discusses the potential of zwitterionic chiral ion-exchangers to support peptide analysis and quality control as a flexible complementary tool to monitor the stereochemical integrity and chemical modifications.