NanoChrom Technologies (Suzhou) Co., Ltd

BioCore HIC column family separate protein-based biotherapeutics and characterizing their critical quality attributes, including DAR and drug distribution in ADCs

This note presents platform methods to characterize ADC using BioCore columns: SEC for aggregate determination, HIC/RP for DAR assesment, CEX for charged variant analysis.

This application note discusses the latest development on high performance cation exchange bio-separation columns for determining charge variants in protein-based biotherapeutics, as well as the strategy on method development.

This application note demonstrates the performance of BioCore SEC columns for determining aggregation and fragmentation associated with antibody-based biotherapeutics.