Column Pore Size—An Underutilized Variable for Optimizing
In advance of Pittcon 2018, leading scientists-Ronald Majors, Richard Henry, John W. Dolan, Zachary S. Breitbach, and Daniel W. Armstrong-who will be speaking at the LCGC awards symposium give us a preview of their talks.
Impact of Particle Size Distribution on HPLC Column Performance
Controlling particle size distribution is examined as a possible route to further improve the performance of particle-based columns.
Practical Tips for Operating UHPLC Instruments and Columns
The authors explain modern UHPLC instrument design and outline simple procedures to identify causes of poor column and method performance.
A Global Approach to HPLC Column Selection Using Reversed Phase and HILIC Modes: What to Try When C18 Doesn't Work
Experimental data are presented to help understand HPLC column retention in a way that should make column selection and method development proceed faster when initial results with C18 columns are disappointing.
The Early Days of HPLC at DuPont
Guest columnist Dick Henry traces the history of HPLC back more than 40 years, starting with his days at DuPont.
Important Guidelines for Optimizing Speed and Sensitivity in Small-Molecule LC-UV and LC-MS
As LC-UV and LC-MS have become preferred instrumental methods for fast, sensitive analysis, many scientists are searching for ways to optimize performance.